Hyaluronan synthase 1 (HAS1) is one of three enzymes, located at the plasma membrane, that synthesizes the glycosaminoglycan hyaluronan or hyaluronic acid (HA). Hyaluronan is involved in cell proliferation, differentiation, angiogenesis, and tumor development, among other cellular processes.
Specificity
This antibody recognizes the cytoplasmic domain of hyaluronan synthase 1.
Immunogen
Epitope: Cytoplasmic domain
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human hyaluronan synthase 1.
Application
Anti-hyaluronan synthase 1 Antibody, clone 12A2.3 is a highly specific mouse monoclonal antibody, that targets Hyaluronan synthase 1 & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected hyaluronan synthase 1 in human ovarian cancer tissues.
Research Category Apoptosis & Cancer
Research Sub Category Apoptosis - Additional
Quality
Evaluated by Western Blotting in HL-60 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detects hyaluronan synthase 1 in 10 µg of HL-60 cell lysate.
Target description
~70 kDa observed
Physical form
Format: Purified
Purified mouse IgMκ supernatant in buffer containing PBS with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control HL-60 cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Cell death and differentiation, 28(7), 2126-2144 (2021-02-17)
Necroptosis is a lytic, inflammatory cell death pathway that is dysregulated in many human pathologies. The pathway is executed by a core machinery comprising the RIPK1 and RIPK3 kinases, which assemble into necrosomes in the cytoplasm, and the terminal effector
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