AB19011
Anti-Tenascin Antibody
Chemicon®, from rabbit
Synonym(s):
Tenascin C
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... TNC(3371)
General description
Tenascin is known to play an active role in development of central nervous system and mesenchymal-derived organs, exist in the vasculature of tumors in adults, and function in cell adhesion.
Specificity
Reactivity with other species has not been confirmed, but likely to react with all mammalian species.
Reacts strongly with tenascin from human and mouse in both Western blotting and immunohistochemistry. While it has not been tested, it should also react strongly in these applications with tenascin from all mammalian species.
Immunogen
Purified human tenascin from glioma culture supernatant.
Application
Research Category
Cell Structure
Cell Structure
Research Sub Category
ECM Proteins
ECM Proteins
This Anti-Tenascin Antibody is validated for use in WB, IH(P) for the detection of Tenascin.
Western blot: 0.5 - 1.0 μg/mL; recognizes 250-350 kDa polypeptides in reduced samples.
Immunohistochemistry: 10 to 20 μg/mL in paraffin embedded tissues
Optimal working dilutions must be determined by end user.
Immunohistochemistry: 10 to 20 μg/mL in paraffin embedded tissues
Optimal working dilutions must be determined by end user.
Physical form
Affinity purified using immobilized human tenascin; presented as a liquid in PBS containing no preservatives.
Storage and Stability
Maintain at -20°C for up to 12 months from date of receipt. Aliquot to avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Loss of caveolin-1 from bronchial epithelial cells and monocytes in human subjects with asthma.
Bains, SN; Tourkina, E; Atkinson, C; Joseph, K; Tholanikunnel, B; Chu, HW; Riemer et al.
Allergy null
Mariska T Meijer et al.
Frontiers in immunology, 12, 600979-600979 (2021-03-30)
Tenascin C (TNC) is an extracellular matrix glycoprotein that recently emerged as an immunomodulator. TNC-deficient (TNC-/-) mice were reported to have a reduced inflammatory response upon systemic administration of lipopolysaccharide, the toxic component of gram-negative bacteria. Here, we investigated the
Fernando García-Marqués et al.
Molecular & cellular proteomics : MCP, 15(5), 1740-1760 (2016-02-20)
The coordinated behavior of proteins is central to systems biology. However, the underlying mechanisms are poorly known and methods to analyze coordination by conventional quantitative proteomics are still lacking. We present the Systems Biology Triangle (SBT), a new algorithm that
Mariska T Meijer et al.
Microbiology spectrum, 9(1), e0020721-e0020721 (2021-07-29)
Tenascin C (TNC) is an extracellular matrix protein with immunomodulatory properties that plays a major role during tissue injury and repair. TNC levels are increased in patients with pneumonia and pneumosepsis, and they are associated with worse outcomes. Methicillin-resistant Staphylococcus
Subhayan Sur et al.
International journal of molecular sciences, 22(6) (2021-04-04)
SARS-CoV-2 infection can cause cytokine storm and may overshoot immunity in humans; however, it remains to be determined whether virus-induced soluble mediators from infected cells are carried by exosomes as vehicles to distant organs and cause tissue damage in COVID-19
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