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Merck

119149

Sigma-Aldrich

Adenosine A2A Receptor Antagonist I, ZM 241385

A highly potent, selective, non-xanthine adenosine A2A receptor antagonist (Ki = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells).

Synonym(s):

Adenosine A2A Receptor Antagonist I, ZM 241385

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About This Item

Empirical Formula (Hill Notation):
C16H15N7O2
CAS Number:
Molecular Weight:
337.34
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Pricing and availability is not currently available.

Quality Level

Assay

≥98% (HPLC)

form

powder

potency

800 pM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 15 mg/mL

application(s)

air monitoring

compatibility

for use with Viable Air Samplers (1.09191)
for use with Viable Air Samplers (1.09194)
for use with Viable Air Samplers (1.17103)
for use with Viable Air Samplers (1.17274)
for use with Viable Air Samplers (1.17275)

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biological source

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antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

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antibody form

affinity isolated antibody

product line

Prestige Antibodies® Powered by Atlas Antibodies

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form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

General description

A highly potent, selective, and orally bioavailable non-xanthine adenosine A2A receptor antagonist (Ki = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells). Does not exhibit any significant antagonistic activity in A1, A2B (Ki = 255 nM and 50 nM, respectively in human adenosine receptors stably expressed in CHO cells) or in A3R (Ki >10 µM in human A3R stably expressed in HEK-293 cells). Shown to have a protective effect against beta-amyloid peptide toxicity.
A highly potent, selective, non-xanthine adenosine A2A receptor antagonist (Ki = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells).

Biochem/physiol Actions

Primary Target
A2A
Reversible: yes

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Poucher, S. M., et al. 1995. Brit. J. Pharmacol. 115, 1096.
Ongini, E. et al. 1999. Naunyn Schmiedebergs Arch Pharmacol. 359, 7.

Keddie, J. et al. 1996, Eur Journ Pharm. 301, 107.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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