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W237418

Sigma-Aldrich

Diethyl malate

≥97%, FG

Synonym(s):

Diethyl 2-hydroxybutanedioate, Hydroxybutane dioic acid diethyl ester, Malic acid diethyl ester

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About This Item

Linear Formula:
C2H5O2CCH2CH(OH)CO2C2H5
CAS Number:
7554-12-3
Molecular Weight:
190.19
FEMA Number:
2374
EC Number:
231-444-5
Council of Europe no.:
382
MDL number:
MFCD00048556
UNSPSC Code:
12164502
PubChem Substance ID:
24901029
Flavis number:
09.439
NACRES:
NA.21

biological source

synthetic

Quality Level

400

grade

FG
Halal

reg. compliance

EU Regulation 1334/2008 & 178/2002
FDA 21 CFR 117
FDA 21 CFR 172.515

Assay

≥97%

bp

122-124 °C/12 mmHg (lit.)

density

1.128 g/mL at 25 °C (lit.)

application(s)

flavors and fragrances

Documentation

see Safety & Documentation for available documents

food allergen

no known allergens

Organoleptic

caramel; fruity; sweet

SMILES string

CCOC(=O)CC(O)C(=O)OCC

InChI

1S/C8H14O5/c1-3-12-7(10)5-6(9)8(11)13-4-2/h6,9H,3-5H2,1-2H3

InChI key

VKNUORWMCINMRB-UHFFFAOYSA-N

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

185.0 °F

Flash Point(C)

85 °C

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Certificates of Analysis (COA)

Lot/Batch Number
SHBP8219
SHBQ1252
SHBP1812
SHBP3981
STBJ6832

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N Chiba et al.
Journal of chromatography. B, Biomedical sciences and applications, 728(1), 35-40 (1999-06-24)
A simple and sensitive method, applicable to quantification of 5-hydroperoxyeicosatetraenoic acid (5-HPETE) produced in cells has been developed using high-performance liquid chromatography on a silica gel column with chemiluminescence detection. 5-HPETE was clearly separated from other positional isomers of HPETEs
J M Messana et al.
The American journal of physiology, 255(5 Pt 2), F874-F884 (1988-11-01)
Glutathione, comprising a major portion of cellular nonprotein thiols, plays a central role in a diverse group of cell metabolic functions. Glutathione and related enzyme systems have been shown to protect against both toxin and oxidant-induced injury in several organ
Oscar A Bizzozero et al.
Journal of neuroscience research, 83(4), 656-667 (2006-02-01)
This study was aimed at establishing whether oxidative stress induced by acute depletion of brain glutathione (GSH) is sufficient to generate protein carbonyls (PCOs). To this end, rat brain slices were incubated separately with the GSH depletors 1,3-bis[2-chloroethyl]-1-nitrosourea (BCNU) and
J M Hansen et al.
Free radical biology & medicine, 31(12), 1582-1592 (2001-12-18)
Glutathione (GSH) is the primary source of reducing equivalents in most cells, contributes significantly to the cellular redox potential and can control differentiation, proliferation, and apoptosis. Using limb bud micromass cultures from Sprague Dawley rats and New Zealand White rabbits
Joo-Young Im et al.
Journal of neuroscience research, 83(2), 301-308 (2005-12-31)
Cadmium is a heavy metal that accumulates in the body, and its accumulation in the brain damages both neurons and glial cells. In the current study, we explored the mechanism underlying cadmium toxicity in primary cortical astroglia cultures. Chronic treatment
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