QBD10211

m-dPEG^®₄-NHS ester

• Synonym(s): 2,5-Dioxo-1-pyrrolidinyl 4,7,10,13-tetraoxatetradecanoate, Polyethylene glycol, Triethylene glycol methyl ether 2-(succinimidyloxycarbonyl)ethyl ether
• Empirical Formula (Hill Notation): C₁₄H₂₃NO₈
• CAS Number: 622405-78-1
• Molecular Weight: 333.33
• MDL number: MFCD11041112
• UNSPSC Code: 12352108
• PubChem Substance ID: 329823894
• NACRES: NA.22

Properties

• Assay: >90%
• form: solid or viscous liquid
• reaction suitability: reagent type: chemical modification reagent; reagent type: cross-linking reagent; reactivity: amine reactive
• polymer architecture: shape: linear; functionality: monofunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O=C1CCC(N1OC(CCOCCOCCOCCOC)=O)=O
• InChI: 1S/C14H23NO8/c1-19-6-7-21-10-11-22-9-8-20-5-4-14(18)23-15-12(16)2-3-13(15)17/h2-11H2,1H3
• InChI key: MAYFFZZPEREGBQ-UHFFFAOYSA-N

Description

Features and Benefits

The m-dPEG^®₄-NHS ester provides a variety of means to modify small molecules, peptides, proteins, and functionalized surfaces (metals, glass, and others). The single molecular weight methoxy-terminated dPEG^® molecules are hydrophilic and non-immunogenic of exact length. Modification with m-dPEG^® reagents can improve water solubility, increase hydrodynamic volume, eliminate or reduce non-specific binding, protect peptides and proteins from proteolysis, reduce or eliminate immunogenicity, and increase serum half-life in vivo. The m-dPEG^®₄-NHS (N-hydroxysuccinimide) ester reacts with amines.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class Code: 11 - Combustible Solids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable