H15403

L-Histidine methyl ester dihydrochloride

97%

• Synonym(s): (S)-Histidine methyl ester dihydrochloride, Methyl L-histidinate dihydrochloride
• Empirical Formula (Hill Notation): C₇H₁₁N₃O₂ · 2HCl
• CAS Number: 7389-87-9
• Molecular Weight: 242.10
• Beilstein: 3572009
• EC Number: 230-973-9
• MDL number: MFCD00012701
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24895465
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 97%
• optical activity: [α]20/D +9.0°, c = 2 in H₂O
• reaction suitability: reaction type: solution phase peptide synthesis
• color: white
• mp: 207 °C (dec.) (lit.)
• application(s): peptide synthesis
• SMILES string: Cl.Cl.COC(=O)[C@@H](N)Cc1c[nH]cn1
• InChI: 1S/C7H11N3O2.2ClH/c1-12-7(11)6(8)2-5-3-9-4-10-5;;/h3-4,6H,2,8H2,1H3,(H,9,10);2*1H/t6-;;/m0../s1
• InChI key: DWAYENIPKPKKMV-ILKKLZGPSA-N

Description

Application

L-Histidine methyl ester dihydrochloride can be used as a reactant to synthesize:

• Imidazopyridine derivatives by Pictet-Spegler reaction with different aldehydes.
• A metal-chelating ligand, N-methacryloyl-(l)-histidine methyl ester by reacting with methacryloyl chloride.
• Zwitterionic polypeptide derivative by amidation reaction with poly (α,β-L-aspartic acid).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves