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Key Documents

938238

Sigma-Aldrich

Silica

monodisperse, non-porous, 5 μm

Synonym(s):

Monodisperse silicon dioxide, Non-porous silica, Non-porous silicon dioxide, Silicon dioxide

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About This Item

Linear Formula:
SiO2
CAS Number:
Molecular Weight:
60.08
MDL number:
UNSPSC Code:
12352309

Quality Level

form

powder

particle size

5 μm

pore size

non-porous

bp

2230 °C (lit.)

mp

>1600 °C (lit.)

SMILES string

O=[Si]=O

InChI

1S/O2Si/c1-3-2

InChI key

VYPSYNLAJGMNEJ-UHFFFAOYSA-N

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General description

Our monodisperse, non-porous silica powder is a white powder composed of speherical particles, precisely engineered to achieve a monodisperse particle size of 5 µm with 99.99% purity. The microparticles do not contain any internal porosity or void spaces, making their surfaces impermeable to fluids or gases.

Application

Monodisperse, non-porous silica particles have several applications in various research areas including drug delivery, molecular imaging, and environmental remediation. Owing to their stable chemical structure, ease of surface modification, and affinity toward various biomolecules, silica microparticles are an attractive platform for bioconjugation of drugs, proteins, DNA, and other biomarkers. Consequently, non-porous silica particles and their bioconjugates are used in biomedical applications for delivering or isolating drugs, proteins, polynucleotides, and more. Bioconjugation of non-porous silica often facilitates imaging techniques including optical imaging (fluorescence and bioluminescence), magnetic resonance imaging (MRI), radionuclide imaging, computed tomography (CT), ultrasound, photoacoustic imaging, and Raman imaging.,Apart from these applications, these monodisperse particles are also used in analytical applications, such as the stationary phase in columns for advanced, high-performance liquid chromatography.

Storage Class Code

11 - Combustible Solids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Nonporous Silica Nanoparticles for Nanomedicine Application
Tang L, et al.
Nano Today, 8, 290-312 (2013)
Safety of Nonporous Silica Nanoparticles in Human Corneal Endothelial Cells
Kim J Y, et al
Scientific Reports, 7, 14566-14566 (2017)
Core-shell particles lead the way to renewing high-performance liquid chromatography
Gonzalez-Ruiz V, et al
TrAC, Trends in Analytical Chemistry, 64, 17-28 (2015)
Nano-Bio Interactions of Porous and Nonporous Silica Nanoparticles of Varied Surface Chemistry: A Structural, Kinetic, and Thermodynamic Study of Protein Adsorption from RPMI Culture Medium
Lehman S, et al.
Langmuir, 32, 731-742 (2016)
Sean E Lehman et al.
Langmuir : the ACS journal of surfaces and colloids, 32(3), 731-742 (2015-12-31)
Understanding complex chemical changes that take place at nano-bio interfaces is of great concern for being able to sustainably implement nanomaterials in key applications such as drug delivery, imaging, and environmental remediation. Typical in vitro assays use cell viability as

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