900893
L-Homopropargylglycine hydrochloride
Synonym(s):
HPG
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About This Item
Empirical Formula (Hill Notation):
C6H9NO2 · HCl
CAS Number:
Molecular Weight:
163.60
UNSPSC Code:
12352209
NACRES:
NA.22
Recommended Products
form
powder or crystals
availability
available only in USA
mp
162 °C
storage temp.
−20°C
SMILES string
O=C(O[H])[C@@](C([H])([H])C([H])([H])C#C[H])([H])N([H])[H].Cl[H]
InChI
1S/C6H9NO2/c1-2-3-4-5(7)6(8)9/h1,5H,3-4,7H2,(H,8,9)
InChI key
SCGJGNWMYSYORS-UHFFFAOYSA-N
Application
L-Homopropargylglycine (HPG) is an amino acid analog of methionine that contains a very small modification, specifically an alkyne moiety. This compound can be fed to cultured cells and incorporated into proteins during active protein synthesis. Detection utilizes the chemoselective ligation or “click” reaction between an azide and an alkyne or cyclooctyne. For example the alkyne-modified protein can be detected with either fluorescent azide or biotin azide. Detection sensitivity with these reagents in 1-D gels and Western blots is in the low femtomole range and compatible with downstream LC-MS/MS and MALDI-MS analysis.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Self-react. C
Storage Class Code
5.2 - Organic peroxides and self-reacting hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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