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86720

Sigma-Aldrich

Tetraethylthiuram disulfide

≥97.0% (S)

Synonym(s):

Bis(diethylthiocarbamoyl) disulfide, Bis(diethylthiocarbamyl) disulfide, Disulfiram, TETD

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About This Item

Linear Formula:
(C2H5)2NCSS2CSN(C2H5)2
CAS Number:
97-77-8
Molecular Weight:
296.54
Beilstein:
1712560
EC Number:
202-607-8
MDL number:
MFCD00009048
UNSPSC Code:
12352100
PubChem Substance ID:
57653188
NACRES:
NA.22

Assay

≥97.0% (S)

form

powder

mp

69-71 °C (lit.)

functional group

amine

SMILES string

CCN(CC)C(=S)SSC(=S)N(CC)CC

InChI

1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3

InChI key

AUZONCFQVSMFAP-UHFFFAOYSA-N

Gene Information

human ... ALDH2(217) , CYP1A2(1544)

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Application

Alcohol dehydrogenase inhibitor.

Signal Word

Warning

Hazard Statements

H302,H317,H373,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT RE 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Peter M Meggyesy et al.
Molecules (Basel, Switzerland), 25(21) (2020-10-31)
The therapeutic utility of the copper ionophore disulfiram was investigated in a diet-induced obesity mouse model (C57BL/6J background), both through administration in feed (0.05 to 1% (w/w)) and via oral gavage (150 mg/kg) for up to eight weeks. Mice were
Beatriz Mothe et al.
The Journal of antimicrobial chemotherapy, 70(6), 1833-1842 (2015-03-01)
The safety, immunogenicity, impact on the latent reservoir and rebound of viral load after therapeutic HIV-1 vaccination with recombinant modified vaccinia Ankara-based (MVA-B) HIV-1 vaccine expressing monomeric gp120 and the fused Gag-Pol-Nef polyprotein of clade B with or without a
Charlotte H Jørgensen et al.
Alcoholism, clinical and experimental research, 35(10), 1749-1758 (2011-05-28)
Alcohol use disorders (AUD) involving hazardous, harmful, and addictive misuse of alcohol are widespread in most parts of the world. The aim of this study was to review the effect of disulfiram in the treatment of patients with AUD. The
Meriem Gaval-Cruz et al.
Molecular interventions, 9(4), 175-187 (2009-09-02)
The anti-alcoholism drug disulfiram (Antabuse), which is an inhibitor of aldehyde dehydrogenase, induces an aversive reaction to alcohol consumption and thereby helps patients reduce alcohol intake. Recent clinical trials, initiated to investigate whether disulfiram could be used to treat individuals
Colin Rae et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(6), 953-960 (2013-04-26)
Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as an anticancer drug and radiosensitizer. Proposed mechanisms of action include the induction of oxidative stress and inhibition of proteasome activity. Our purpose was
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