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75892

Sigma-Aldrich

α-Ketoglutaric acid disodium salt dihydrate

≥98.0% (dried material, NT)

Synonym(s):

2-Oxoglutaric acid disodium salt, Sodium α-ketoglutarate dibasic

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About This Item

Linear Formula:
NaOOCCH2CH2COCOONa · 2H2O
CAS Number:
1282616-74-3
Molecular Weight:
226.09
Beilstein:
5658566
EC Number:
206-167-8
MDL number:
MFCD00150702
UNSPSC Code:
12352100
PubChem Substance ID:
57652590
NACRES:
NA.22

Quality Level

200

Assay

≥98.0% (dried material, NT)

form

powder

impurities

~16% water

functional group

ketone

SMILES string

O.O.[Na+].[Na+].[O-]C(=O)CCC(=O)C([O-])=O

InChI

1S/C5H6O5.2Na.2H2O/c6-3(5(9)10)1-2-4(7)8;;;;/h1-2H2,(H,7,8)(H,9,10);;;2*1H2/q;2*+1;;/p-2

InChI key

HSSWOFWCOAQLHZ-UHFFFAOYSA-L

General description

α-Ketoglutaric acid disodium salt dihydrate (2-Oxoglutaric acid disodium salt) is the hydrated disodium salt of 2-oxoglutaric acid.

Application

α-Ketoglutaric acid disodium salt dihydrate (2-Oxoglutaric acid disodium salt) may be used as starting reagent for the synthesis of deuteriated 2-oxo[3,3-2H2]glutarate disodium salt.
α-Ketoglutaric acid disodium salt dihydrate is suitable reagent used in a study to investigate the role of nitric oxide (NO) in mast cell physiology and biochemistry.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kisakurek MV.
Hominatio: An International Tribute to Albert Eschenmoser, 2557-2557 (2001)
Li-Li Chen et al.
Journal of molecular modeling, 19(4), 1919-1927 (2013-01-23)
Bacillus subtilis natto is widely used in industry to produce natto, a traditional and popular Japanese soybean food. However, during its secondary fermentation, high amounts of ammonia are released to give a negative influence on the flavor of natto. Glutamate
Agata M Pudlik et al.
Applied and environmental microbiology, 79(4), 1095-1101 (2012-12-04)
Transamination is the first step in the conversion of amino acids into aroma compounds by lactic acid bacteria (LAB) used in food fermentations. The process is limited by the availability of α-ketoglutarate, which is the best α-keto donor for transaminases
E Tomaszewska et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 63(5), 547-554 (2012-12-06)
The potential effects of prenatal administration of dexamethasone (DEX) and postnatal treatment with 2-oxoglutaric acid (2-Ox) on postnatal development of connective tissue of farm animals were not examined experimentally. The aim of this study was to establish changes in morphological
Piotr Dobrowolski et al.
Nutrition (Burbank, Los Angeles County, Calif.), 29(3), 556-561 (2012-12-12)
Proton-pump inhibitors, such as omeprazole, are widely used in the prevention and treatment of gastroesophageal diseases. However, an association between proton-pump inhibitors and the increased risk of bone fractures has been observed, especially in patients treated for extended periods. Conversely
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