488712

Trimethyl(trifluoromethyl)silane

99%

• Synonym(s): (Trifluoromethyl)trimethylsilane, Ruppert’s Reagent, TFMTMS
• Linear Formula: (CH₃)₃SiCF₃
• CAS Number: 81290-20-2
• Molecular Weight: 142.19
• Beilstein: 4241868
• MDL number: MFCD00145454
• UNSPSC Code: 12352101
• PubChem Substance ID: 24872418
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: 99%
• reaction suitability: reaction type: C-C Bond Formation
• bp: 54-55 °C (lit.)
• density: 0.962 g/mL at 20 °C (lit.)
• functional group: fluoro
• storage temp.: 2-8°C
• SMILES string: C[Si](C)(C)C(F)(F)F
• InChI: 1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3
• InChI key: MWKJTNBSKNUMFN-UHFFFAOYSA-N

Description

Application

Trimethyl(trifluoromethyl)silane can be used as a trifluoromethylating agent in the following processes:

• Conversion of N-(tert-butylsulfinyl)-imines to trifluoromethylated amines
• Conversion of trans-enones to trans-α-trifluoromethyl silyl ethers
• Trifluoromethylation of azomethine imines
• Conversion of H-phosphonates to CF₃-phosphonates
• Nucleophilic addition of the trifluoromethyl group to aldehydes and ketones.

Safety Information

• Pictograms: GHS02
• Signal Word: Danger
• Hazard Statements: H225,H261
• Precautionary Statements: P210 - P223 - P231 + P232 - P233 - P240 - P241
• Hazard Classifications: Flam. Liq. 2 - Water-react 2
• Storage Class Code: 4.3 - Hazardous materials which set free flammable gases upon contact with water
• WGK: WGK 3
• Flash Point(F): 1.4 °F - closed cup
• Flash Point(C): -17 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves