44570

Dowtherm^® A

eutectic mixture of 26.5% diphenyl + 73.5% diphenyl oxide

• Synonym(s): Diphyl
• MDL number: MFCD00148859
• UNSPSC Code: 12352100
• PubChem Substance ID: 57650233
• NACRES: NA.22

Properties

• Quality Level: 100
• refractive index: n20/D 1.590
• mp: 12-14 °C (lit.)
• functional group: phenoxy; phenyl
• SMILES string: c1ccc(cc1)-c2ccccc2.O(c3ccccc3)c4ccccc4
• InChI: 1S/C12H10O.C12H10/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12;1-3-7-11(8-4-1)12-9-5-2-6-10-12/h1-10H;1-10H
• InChI key: MHCVCKDNQYMGEX-UHFFFAOYSA-N

Description

General description

Dowtherm^® A is a thermally stable organic heat transfer fluid composed of a eutectic mixture of highly stable compounds, biphenyl, and diphenyl oxide. Dowtherm^® A is suitable for high-temperature heat transfer applications up to 400 °C. This fluid can be used in both liquid and vapor phase systems.

Application

Dowtherm^® A can be used as a high boiling solvent in cyclization reactions. For example, it is used to synthesize:      

• 1-Hydroxy-5-methoxy-1,2-dihydrobenzo[f][2,7]naphthyridines from 2-chloro-3-formyl quinolines.     
• Isoindolinone derivatives via intramolecular Diels–Alder cycloaddition reactions of substituted pyridazines.
• Phosphorylated azaheterocycles from 2-diethoxyphosphoryl-3-methoxyacrylate via intramolecular cyclizations under thermal conditions.

Legal Information

DOWTHERM is a registered trademark of The Dow Chemical Company or an affiliated company of Dow

Safety Information

• Pictograms: GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H315 - H319 - H335 - H410
• Precautionary Statements: P261 - P264 - P271 - P273 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves