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263389

Sigma-Aldrich

3,5-Bis(trifluoromethyl)benzylamine

technical grade, 80%

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About This Item

Linear Formula:
(CF3)2C6H3CH2NH2
CAS Number:
85068-29-7
Molecular Weight:
243.15
Beilstein:
7209267
EC Number:
285-290-9
MDL number:
MFCD00009909
UNSPSC Code:
12352100
PubChem Substance ID:
24855967
NACRES:
NA.22

grade

technical grade

Assay

80%

form

solid

mp

50-55 °C (lit.)

functional group

amine
fluoro

SMILES string

NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI

1S/C9H7F6N/c10-8(11,12)6-1-5(4-16)2-7(3-6)9(13,14)15/h1-3H,4,16H2

InChI key

DHVHORCFFOSRBP-UHFFFAOYSA-N

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Application

3,5-Bis(trifluoromethyl)benzylamine has been used in the preparation of phenyl glycine derivatives.

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

172.4 °F - closed cup

Flash Point(C)

78 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW9201
MKCV3590
MKCS5760
MKCR4977
MKCQ3038

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Lihu Yang et al.
Bioorganic & medicinal chemistry letters, 16(14), 3735-3739 (2006-05-16)
Systematic modification of a screening lead yielded a class of potent glycinamide based CCR2 antagonists. The best compound (55, (2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-{[2-(1-piperidinyl)ethyl]amino}-2-(3-thienyl)acetamide) displayed good binding affinity (IC50=30 and 39 nM) toward human monocytes and CHO cell expressing human CCR2b, respectively. Functionally, it

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