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145300

Sigma-Aldrich

3,4-(Methylenedioxy)phenylacetonitrile

99%

Synonym(s):

1,3-Benzodioxole-5-acetonitrile, Homopiperonylnitrile

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About This Item

Empirical Formula (Hill Notation):
C9H7NO2
CAS Number:
4439-02-5
Molecular Weight:
161.16
Beilstein:
7739
EC Number:
224-655-9
MDL number:
MFCD00005835
UNSPSC Code:
12352100
PubChem Substance ID:
24848716
NACRES:
NA.22

Assay

99%

mp

43-45 °C (lit.)

functional group

nitrile

SMILES string

N#CCc1ccc2OCOc2c1

InChI

1S/C9H7NO2/c10-4-3-7-1-2-8-9(5-7)12-6-11-8/h1-2,5H,3,6H2

InChI key

ZQPBOYASBNAXOZ-UHFFFAOYSA-N

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General description

3,4-(Methylenedioxy)phenylacetonitrile undergoes hydrolysis catalyzed by nitrilase ZmNIT2 enzyme from maize.

Application

3,4-(Methylenedioxy)phenylacetonitrile was used in synthesis of derrubone. It was used as standard to analyze the seized methamphetamine samples showing unique profiles of stable isotopic compositions by isotope ratio mass spectrometry.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBD1937V
S35314-189
03303PW
02318DE
S35314

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Jedidiah M Hastings et al.
The Journal of organic chemistry, 73(2), 369-373 (2007-12-25)
Recently, we reported that the natural product derrubone exhibits Hsp90 inhibitory activity. Due to its unique architectural scaffold and proposed rapid assembly, the synthesis of this natural product was pursued with the aim of identifying structure--activity relationships. Synthesis of the
Seized methamphetamine samples with unique profiles of stable nitrogen isotopic composition documented by stable isotope ratio mass spectrometry.
Iwata YT, et al.
Forensic Toxicology, 28(2), 119-123 (2010)
Enzymatic nitrile hydrolysis catalyzed by nitrilase ZmNIT2 from maize. An unprecedented ?-hydroxy functionality enhanced amide formation.
Mukherjee C, et al.
Tetrahedron, 62(26), 6150-6154 (2006)

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