11373

HATU

≥98.0% (CHN), for peptide synthesis

• Synonym(s): 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, N-[(Dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide
• Empirical Formula (Hill Notation): C₁₀H₁₅F₆N₆OP
• CAS Number: 148893-10-1
• Molecular Weight: 380.23
• MDL number: MFCD27957364
• UNSPSC Code: 12352302
• PubChem Substance ID: 57646915
• NACRES: NA.22

Properties

• product name: HATU, ≥98.0% (CHN)
• Assay: ≥98.0% (CHN)
• form: solid
• reaction suitability: reaction type: Coupling Reactions
• mp: 183-185 °C (lit.); 183-188 °C (dec.)
• application(s): peptide synthesis
• functional group: amine
• storage temp.: 2-8°C
• SMILES string: F[P-](F)(F)(F)(F)F.CN(C)[C+](N(C)C)n1n[n+]([O-])c2ncccc12
• InChI: 1S/C10H15N6O.F6P/c1-13(2)10(14(3)4)15-8-6-5-7-11-9(8)16(17)12-15;1-7(2,3,4,5)6/h5-7H,1-4H3;/q+1;-1
• InChI key: FKBFHOSFPRWJNV-UHFFFAOYSA-N

Description

Application

Reagent for:
Synthesis of Aurora A kinase inhibitors
HPLC assay to determine D- and L- acid enantiomers in human plasma
Amide bond formation reactions

Catalyst for:
Selective acylation
Selecocyclization-oxidation deselenation sequence

Other Notes

Recent studies show that crystal as well as solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound; Advantageous coupling reagent for solid-phase peptide synthesis.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H317,H334
• Precautionary Statements: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1A
• Supplementary Hazards: EUH044
• Storage Class Code: 4.1A - Other explosive hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves