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Key Documents

SAB4500148

Sigma-Aldrich

Anti-Cofilin antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CFL, CFL1, CFL2, Cofilin 2, Cofilin-1

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About This Item

MDL number:
MFCD03791485
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 18 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI accession no.

Q9Y281

UniProt accession no.

P23528

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CFL2(1073)

Related Categories

General description

Anti-Cofilin Antibody detects endogenous levels of total Cofilin protein.

Cofilin is a member of the actin depolymerizing factor/cofilin family. Among all members, cofilin‐1 is the predominant isoform. It is located on human chromosome 11q13.

Immunogen

The antiserum was produced against synthesized peptide derived from human Cofilin.

Immunogen Range: 61-110

Application

Anti-Cofilin antibody has been used in western blotting.

Biochem/physiol Actions

Cofilin plays an important role in actin filament remodeling that is required in chemotaxis, cell migration and invasion of tumor cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pricing

Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14
Gillett GT, et al.
Annals of Human Genetics, 60 (1996)
Jun-Bum Park et al.
Oncotarget, 5(19), 9382-9395 (2014-09-23)
Malignant gliomas are highly proliferative and invasive neoplasms where total surgical resection is often impossible and effective local radiation therapy difficult. Consequently, there is a need to develop a greater understanding of the molecular events driving invasion and to identify
Immune-complex level of cofilin-1 in sera is associated with cancer progression and poor prognosis in pancreatic cancer
Satoh M, et al.
Cancer Science, 108, 795-803 (2017)
Irena Audzeyenka et al.
Journal of cellular physiology, 236(6), 4655-4668 (2020-11-28)
Insulin plays a major role in regulating glucose homeostasis in podocytes. Protein kinase G type Iα (PKGIα) plays an important role in regulating glucose uptake in these cells. Rac1 signaling plays an essential role in the reorganization of the actin
Irena Audzeyenka et al.
Biochimica et biophysica acta. Molecular cell research, 1867(8), 118723-118723 (2020-04-18)
A growing body of evidence suggests a role of proteolytic enzymes in the development of diabetic nephropathy. Cathepsin C (CatC) is a well-known regulator of inflammatory responses, but its involvement in podocyte and renal injury remains obscure. We used Zucker

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