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Key Documents

SAB4300781

Sigma-Aldrich

Anti-SLCO1B1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

LST-1, Liver-specific organic anion transporter 1, OATP 2, Sodium-independent organic anion-transporting polypeptide 2, Solute carrier family 21 member 6

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

76 kDa

species reactivity

human

concentration

1.0 mg/mL

technique(s)

western blot: 1:500-1:3000 (Cell Lysate)

isotype

IgG

accession no.

NP_006437.3

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SLCO1B1(10599)

General description

Solute carrier organic anion transporter family member 1B1 (SLCO1B1) or liver-specific organic anion transporter 1 (LST-1) and sodium-independent organic anion-transporting polypeptide 2 (OATP-2), is formerly known as solute carrier family 21 (organic anion transporter), member 6 (SLC21A6). SLCO1B1 is predominantly expressed in liver. It is expressed in the basolateral membrane. It has 12 transmembrane domains. In human chromosome, the gene SLCO1B1 is localized on 12p12.1

Specificity

The antibody detects endogenous levels of total SLCO1B1 protein.

Immunogen

Synthesized peptide derived from internal of human SLCO1B1.

Biochem/physiol Actions

Solute carrier organic anion transporter family member 1B1 (SLCO1B1) transports taurocholate, conjugated steroids, eicosanoids, and thyroid hormones, in a sodium independent manner. SLCO1B1 is the key transporter of bile for the clearance of human liver. Polymorphism in SLCO1B1 might lead to life threatening drug toxicities. Mutations in SLCO1B1 and SLCO1B3 leads to rotor syndrome in human, affecting conjugated bilirubin reuptake in liver. Genetic variability in SLCO1B1 affects the plasma concentration of statins.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy
Wilke RA, et al.
Clinical Pharmacology and Therapeutics, 92(1), 112-117 (2012)
Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1
Abe T, et al.
The Journal of Biological Chemistry, 274(24), 17159-17163 (1999)
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
Ko?nig J, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 278(1), G156-G164 (2000)
Integrative genomics strategies to elucidate the complexity of drug response
Kasarskis A, et al.
Pharmacogenomics, 12(12), 1695-1715 (2011)
Evita van de Steeg et al.
The Journal of clinical investigation, 122(2), 519-528 (2012-01-11)
Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood, resulting in jaundice. The mechanistic basis of bilirubin excretion

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