SAB4300153

Anti-phospho-APP (^p668) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-AAA antibody produced in rabbit, Anti-ABETA antibody produced in rabbit, Anti-ABPP antibody produced in rabbit, Anti-AD1 antibody produced in rabbit, Anti-amyloid beta (A4) precursor protein antibody produced in rabbit
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 100-140 kDa
• species reactivity: rat, human, mouse
• concentration: 1 mg/mL
• technique(s): western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (A-V-TP-P-E)
• NCBI accession no.: NP_000475.1
• UniProt accession no.: P05067
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pThr668)
• Gene Information: human ... APP(351)

Description

Immunogen

Peptide sequence around phosphorylation site of threonine 668 (A-V-T(p)-P-E), according to the protein APP.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable