S2812

SNC80

≥98% (HPLC), solid

• Synonym(s): (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide, SNC 80, SNC-80
• Empirical Formula (Hill Notation): C₂₈H₃₉N₃O₂
• CAS Number: 156727-74-1
• Molecular Weight: 449.63
• MDL number: MFCD00672673
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278698
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: off-white
• solubility: DMSO: soluble
• SMILES string: CCN(CC)C(=O)c1ccc(cc1)[C@H](N2C[C@H](C)N(CC=C)C[C@H]2C)c3cccc(OC)c3
• InChI: 1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27?/m0/s1
• InChI key: KQWVAUSXZDRQPZ-QNWUEUMSSA-N
• Gene Information: human ... OPRD1(4985) ; mouse ... Oprd1(18386) ; rat ... Oprd1(24613) , Oprm1(25601)

Description

Application

Rats were administered SNC80 to study the role of nitric oxide synthase in peripheral antinociception mechanism.⁵

Biochem/physiol Actions

SNC80 is a highly selective agonist of δ opioid receptor but also binds to μ-δ opioid receptor heteromers to produce antinociception in mice.² It also acts as anti-depressant³, elicits dopamine-related behaviors and enhances behavioral responses to psychostimulants.⁴

SNC80 is a δ opioid receptor agonist.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves