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GE17-5269-02

MabSelect™ Xtra

Cytiva 17-5269-02, pack of 200 mL

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About This Item

UNSPSC Code:
41106500
NACRES:
NA.56

ligand

recombinant protein A (E. coli)

packaging

pack of 200 mL

manufacturer/tradename

Cytiva 17-5269-02

storage condition

(20% Ehtanol)

matrix

highly cross-linked agarose

avg. part. size

75 (d₅₀v is the median particle size of the cumulative volume distribution)

cleaning in place

2-12

working range

3-10

capacity

≥30 mg binding capacity (humanlgG/ml at 2.4 min residence time)

suitability

suitable for bioprocess medium

storage temp.

2-8°C

General description

Determined at 10% breakthrough by frontal analysis at a mobile phase velocity of 500 cm/h in a column with a bed height of 20 cm.
MabSelect™ Xtra, with extra high dynamic binding capacity, is a member of the MabSelect™ family. Developed to meet the demands of increasing levels of expression in monoclonal antibody feedstocks.
pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.
pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.

Application

MabSelect™ Xtra has the same recombinant Protein A ligand as MabSelect™ but is based on a high-fLow Agarose base matrix with increased porosity and a slightly decreased particle size compared to MabSelect. This results in higher capacity—MabSelect™ Xtra has about 30% higher dynamic binding capacity for IgG than currently available Protein A chromatography media. In addition, MabSelect™ Xtra has a higher capacitiy for many Fc-fusion Proteins.

The medium provides a lower overall production cost due to the possibility of processing concentrated feedstocks in fewer batches.

MabSelect™ Xtra is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development. As member of the BioProcess media range, MabSelect™ Xtra meets industrial demands with security of supply and comprehensive technical and regulatory support.

Features and Benefits

  • Higher dynamic binding capacity than currently available Protein A chromatography media.
  • Improved process economics through reduced raw materials costs and/or reduced number of cycles
  • High purity capture due to high ligand selectivity and matrix hydrophilicity
  • Slightly lower pressure/fLow properties compared to MabSelect™ SuRe™ and MabSelect

Storage and Stability

Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.

Analysis Note

To view the Certificate of Analysis for this product, please visit www.cytiva.com.

Legal Information

MabSelect is a trademark of Cytiva
SuRe is a trademark of Cytiva

Pictograms

Flame
GHS02

Signal Word

Warning

Hazard Statements

H226

Storage Class Code

3 - Flammable liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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