FLAAS

Adenosine 5′-triphosphate (ATP) disodium salt hydrate

vial of ~1 mg ATP

• Synonym(s): ATP disodium hydrate
• Linear Formula: C₁₀H₁₄N₅O₁₃P₃Na₂ · xH₂O
• CAS Number: 34369-07-8
• Molecular Weight: 551.14 (anhydrous basis)
• EC Number: 213-579-1
• MDL number: MFCD00150755
• UNSPSC Code: 12352202
• eCl@ss: 32160414
• PubChem Substance ID: 24895005
• NACRES: NA.26

Properties

• biological source: bacterial (Corynebacterium sp)
• Quality Level: 200
• Assay: ≥90%
• form: lyophilized powder
• packaging: vial of ~1 mg ATP
• storage temp.: −20°C
• SMILES string: Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O
• InChI: 1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1
• InChI key: NTBQNWBHIXNPRU-MSQVLRTGSA-L

Description

Application

Adenosine 5′-triphosphate (ATP) disodium salt hydrate has been:

• used as a standard to measure ATP by bioluminescence method[1]
• used in kinase buffer to assess the interaction between death-associated protein kinases (DAPK2) and 14-3-3-β[2]
• used as a standard in ATP colorimetric assay[3]

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is one of the nucleoside triphosphate present in living system. It controls various biologic processes such as glucose metabolism, muscle contraction and neurotransmission. Apart from this, ATP serves as an important energy source for the cell. Administration of ATP might be useful in the treatment of non-small-cell lung cancer.[4]

Adenosine 5′-triphosphate was shown to have inhibitory effects on the inflammatory response by abrogating secretion of TNF-α and promoting secretion of Interleukin-10. [5]

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems

Quantity

Each vial contains ~1.2 mg of Na₂ATP • 3H₂O equivalent to ~1.0 mg of ATP (2.0 μmol). Actual amount printed on the label.

Preparation Note

Prepared to be substantially vanadium-free.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves