E9530
Erythropoietin from mouse
recombinant, expressed in NSO cells, ≥90% (SDS-PAGE), lyophilized powder, suitable for cell culture
Synonym(s):
EPO
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About This Item
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biological source
mouse
Quality Level
recombinant
expressed in NSO cells
Assay
≥90% (SDS-PAGE)
form
lyophilized powder
potency
1.030 ng/mL
mol wt
~36 kDa by SDS-PAGE
predicted mol wt 18.6 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Epo(13856)
General description
EPO (erythropoietin) gene is localized to human chromosome 7q22. This protein is predominantly produced by the cortex cells of kidney, as well as a variety of tissues including female reproductive organs. It is a glycoprotein, which has a molecular weight of 34kDa. It is produced as a 193-amino acid precursor protein, which is cleaved to produce a secreted protein of 166-amino acid.
Biochem/physiol Actions
EPO (erythropoietin) plays an essential role in the growth and differentiation of erythrocyte progenitor cells. It is involved in the pathogenesis of myomatous erythrocytosis syndrome, which is characterized by erythrocytosis and myomatous uterus. It acts as a ligand for a homodimer of EPO-receptor (Epo-R), which is localized to the surface of immature erythroid cells. This interaction leads to inhibition of apoptosis and facilitation of cell proliferation and differentiation to mature erythrocytes.
Erythropoietin is a glycoprotein that is the principal regulator of red blood cell growth and differentiation.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.
Analysis Note
The biological acitivity is measured by its ability to stimulate cell proliferation using TF-1 cell line.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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L T Vlasveld et al.
The Netherlands journal of medicine, 66(7), 283-285 (2008-07-30)
Myomatous erythrocytosis syndrome is defined by the combination of erythrocytosis, myomatous uterus and persistent restoration of normal haematological values after hysterectomy. A pathogenic role of erythropoietin is suggested by clinical and experimental data. A postmenopausal patient is described with the
Norio Suzuki
The Tohoku journal of experimental medicine, 235(3), 233-240 (2015-03-20)
Erythrocytes play an essential role in the delivery of oxygen from the lung to every organ; a decrease in erythrocytes (anemia) causes hypoxic stress and tissue damage. To maintain oxygen homeostasis in adult mammals, when the kidney senses hypoxia, it
Sheila E Francis
Methods in molecular biology (Clifton, N.J.), 330, 331-340 (2006-07-19)
The development of techniques for the in vitro differentiation of mouse embryonic stem (ES) cells has provided researchers with the tools to investigate vascular development as would occur in an early embryo. Mice lacking the vascular integrins have various defects
Honghao Zhang et al.
Experimental and therapeutic medicine, 10(5), 1925-1930 (2015-12-08)
Chronic kidney disease (CKD) is commonly accompanied by inflammation and anemia; however, the pathogenesis of CKD is unclear. Expression of resistin, a cysteine-rich secretory plasma protein, is correlated with the expression of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and lipoprotein-associated
High-Dose Ribavirin Enhances Early Virological Response in Hepatitis C Genotype 1-Infected Patients.
Karin Lindahl et al.
Therapeutic drug monitoring, 37(6), 745-750 (2015-03-27)
The aim of the study was to investigate whether patients with a previous nonresponse to standard of care treatment with ribavirin dosed according to body weight would respond to a high individualized dose of concentration-monitored ribavirin. Previous nonresponders to standard
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