A4737
Bovine Serum Albumin
lyophilized powder, protease, essentially free, ≥98% (agarose gel electrophoresis)
Synonym(s):
Albumin from bovine serum, Albumin bovine serum, BSA, Bovine albumin
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About This Item
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biological source
bovine
Assay
≥98% (agarose gel electrophoresis)
form
lyophilized powder
mol wt
~66 kDa
packaging
poly bottle of
origin
New Zealand origin
technique(s)
ligand binding assay: suitable
impurities
≤8.0% water (Karl Fischer)
pH
4.8-7.5
solubility
H2O: soluble 50 mg/mL
UniProt accession no.
foreign activity
protease, essentially free
storage temp.
2-8°C
Gene Information
bovine ... ALB(280717)
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General description
The most abundant plasma protein in mammals is albumin. It is produced in the liver and transferred as a non-glycosylated protein into the plasma. This multifunctional protein can bind to ligands.
Application
Bovine serum albumin (BSA) is extensively used for drug delivery since it is widely available, cheap and easily purified, has ligand-binding properties, and is widely accepted in the pharmaceutical industry.
Biochem/physiol Actions
Albumin is the most important circulatory protein involved in the control of Ca2+ (and Mg2+) levels in mammals.
Certain conformational and primary-sequence epitopes of BSA are suspected allergens in human beef and milk allergies.
Preparation Note
Purified by chromatography
Serum albumin may be referred to as Fraction V. This naming convention is taken from the original Cohn method of fractionating serum proteins using cold ethanol precipitation. Serum albumin was found in the fifth ethanol fraction using Cohn′s method. Since then, the term "Fraction V" has been used by some to describe serum albumin regardless of the method of preparation. Others have used this term to describe serum albumin purified by ethanol fractionation methods that have been highly modified since the original Cohn method was described. Sigma-Aldrich manufactures and distributes serum albumins purified from a variety of primary methods including the true Cohn fractionation method, modified ethanol fractionation methods, heat shock and chromatography. Additional purification steps may include crystallization or charcoal filtration.
Sourced and manufactured in New Zealand
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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