86339

Sodium taurocholate hydrate

≥97.0% (TLC)

• Synonym(s): Taurocholic acid sodium salt
• Empirical Formula (Hill Notation): C₂₆H₄₄NNaO₇S · xH₂O
• CAS Number: 345909-26-4
• Molecular Weight: 537.68 (anhydrous basis)
• Beilstein: 3901620
• EC Number: 205-653-7
• MDL number: MFCD00150819
• UNSPSC Code: 12161902
• PubChem Substance ID: 57653098
• NACRES: NA.77

Properties

• biological source: ox bile; synthetic
• Quality Level: 200
• description: anionic
• Assay: ≥97.0% (TLC)
• form: powder
• optical activity: [α]20/D +23±1°, c = 3% in H₂O (dry matter)
• mol wt: 537.68 g/mol (anhydrous basis)
• impurities: ≤1% taurine; ≤2% cholic acid
• solubility: H₂O: 50 mg/mL, clear
• functional group: sulfonic acid
• SMILES string: O.[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
• InChI: 1S/C26H45NO7S.Na.H2O/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29;;/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34);;1H2/q;+1;/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-;;/m1../s1
• InChI key: RDAJAQDLEFHVNR-NEMAEHQESA-M

Description

Application

Sodium taurocholate hydrate was used as an emulsifier in in situ preparation of digestive enzymes.[1]

Biochem/physiol Actions

Taurocholic acid is the main end product of cholesterol catabolism. During enterohepatic circulation, bile taurocholic acid is converted by the microorganisms to taurodeoxycholic acid and deoxycholic acid.[2] These are reabsorbed by the liver via a carrier-mediated process and converted by liver enzymes to taurocholic acid.[2][3]

Preparation Note

Sodium taurocholate hydrate yields a clear, colorless solution in water at 50 mg/ml.

Other Notes

For the solubilization of unconjugated bilirubin[4]

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves