36799
7-(Diethylamino)coumarin-3-carboxylic acid
BioReagent, suitable for fluorescence, ≥98.0% (HPCE)
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About This Item
Empirical Formula (Hill Notation):
C14H15NO4
CAS Number:
Molecular Weight:
261.27
Beilstein:
6145963
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.32
Recommended Products
product line
BioReagent
Assay
≥98.0% (HPCE)
mp
222-224 °C (dec.) (lit.)
solubility
DMF: soluble
DMSO: soluble
fluorescence
λex 409 nm; λem 473 nm in 0.1 M Tris pH 9.0
suitability
suitable for fluorescence
SMILES string
CCN(CC)c1ccc2C=C(C(O)=O)C(=O)Oc2c1
InChI
1S/C14H15NO4/c1-3-15(4-2)10-6-5-9-7-11(13(16)17)14(18)19-12(9)8-10/h5-8H,3-4H2,1-2H3,(H,16,17)
InChI key
WHCPTFFIERCDSB-UHFFFAOYSA-N
Application
7-(Diethylamino)coumarin-3-carboxylic acid (7-DCCA) may be used to study its photophysical properties in various solvents and solvent mixtures and as a fluorescent label for amine modification and protein conjugation
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
Fluorescent label for amine modification and protein conjugation
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Keisuke Ikeda et al.
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Amyloid beta-protein (Abeta) has been reported to interact with a variety of lipid species, although the thermodynamic driving force remains unclear. We investigated the binding of Abetas labeled with the dye diethylaminocoumarin (DAC-Abetas) to lipid bilayers under various conditions. DAC-Abeta-(1-40)
Aninda Chatterjee et al.
Photochemistry and photobiology, 89(2), 280-293 (2012-09-26)
The photophysical properties of 7-(diethylamino) coumarin-3-carboxylic acid (7-DCCA) were studied in cyclodextrins (α, β, γ,-CDs), different neat solvents and solvent mixtures by using steady state absorption, emission and time-resolved fluorescence spectroscopy. We have observed that with gradual increase in concentration
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GM1 ganglioside-bound amyloid beta-protein (GM1/Abeta), found in brains exhibiting early pathological changes of Alzheimer's disease (AD) including diffuse plaques, has been suggested to be involved in the initiation of amyloid fibril formation in vivo by acting as a seed. To
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