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P2256

Sigma-Aldrich

Sodium pyruvate

ReagentPlus®, ≥99%

Synonym(s):

α-Ketopropionic acid sodium salt, 2-Oxopropanoic acid sodium salt, Pyruvic acid sodium salt

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About This Item

Linear Formula:
CH3COCOONa
CAS Number:
113-24-6
Molecular Weight:
110.04
Beilstein:
3568341
EC Number:
204-024-4
MDL number:
MFCD00002586
UNSPSC Code:
12352100
PubChem Substance ID:
24898303
NACRES:
NA.21
Assay:
≥99%
form:
powder
solubility:
H2O: 100 mg/mL, clear, colorless to faintly yellow
Pricing and availability is not currently available.

Quality Level

200

product line

ReagentPlus®

Assay

≥99%

form

powder

loss

≤0.5% loss on drying

mp

>300 °C (lit.)

solubility

H2O: 100 mg/mL, clear, colorless to faintly yellow

cation traces

heavy metals (as Pb): ≤20 ppm

functional group

ketone

storage temp.

2-8°C

SMILES string

[Na+].CC(=O)C([O-])=O

InChI

1S/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1

InChI key

DAEPDZWVDSPTHF-UHFFFAOYSA-M

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General description

Sodium pyruvate (SP) is a simplest keto-acid. It crystallizes as very thin plates and belongs to the monoclinic system.[1] Its utility in Knoevenagel condensation carried out in an aqueous medium has been examined.[2] The standard molar enthalpy of formation and molar enthalpy of dissolution of SP at infinite dilution have been obtained.[3] Its efficacy in treating mitochondrial DNA depletion syndromes has been investigated.[4]

Application

Sodium pyruvate has been used:
  • To prepare Bull Tyrode′s albumin-lactate-pyruvate diluent.[5]
  • In pyruvate tolerance test.[6]
  • To prepare oligodendrocyte culture medium.[7]

Other Notes

Go to Redi-Dri™ Product Listing 792500

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317,H319

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1B

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000422397
0000422397
0000422395
0000422395
0000421069

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The crystal structure of sodium pyruvate.
Tavale SS, et al.
Acta Crystallographica, 14(12), 1281-1286 (1961)
Pyruvate therapy for mitochondrial DNA depletion syndrome.
Saito K, et al.
Biochim. Biophys. Acta Gen. Subj., 1820(5), 632-636 (2012)
"On Water": Rapid Knoevenagel Condensation Using Sodium Pyruvate.
Heravi MM, et al.
Letters in Organic Chemistry, 3(4), 297-299 (2006)
Donald A Morgan et al.
Diabetes, 64(6), 1976-1987 (2015-01-22)
Melanocortin 4 receptor (MC4R) signaling mediates diverse physiological functions, including energy balance, glucose homeostasis, and autonomic activity. Although the lateral hypothalamic area (LHA) is known to express MC4Rs and to receive input from leptin-responsive arcuate proopiomelanocortin neurons, the physiological functions
Crystal structure and thermochemical properties of a novel coordination compound sodium pyruvate C3H3O3Na(s).
Gao ZF, et al.
The Journal of Chemical Thermodynamics, 78, 189-196 (2014)
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Questions

1–4 of 4 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. Could you please specify the stability period of Pyruvate after it has been reconstituted? Is there an effective method for the long-term storage of Pyruvate once it has been reconstituted in DMSO? Could you provide the recommended storage conditions?

    1 answer

    1. The sodium pyruvate powder is intended to be stored at 2-8°C. A stability study of this chemical reconstituted in DMSO has not been evaluated. There is an aqueous solution option for sodium pyruvate that is sterile-filtered as product S8636. This specific product is stable for up to 24 months when stored at 2-8°C.

      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/189/461/s8636pis.pdf

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  4. what is the concentration of 5 g sodium pyruvate acid

    1 answer

    1. Sodium pyruvate - P2256 is a powder that has a purity of 100%.

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