ALD00613

PSI²

• Synonym(s): Ψ², 2-(Perfluorophenoxy)-1,3,2-dithiaphospholane 2-sulfide, Achiral phosphorus-sulfur Incorporation reagent
• Empirical Formula (Hill Notation): C₈H₄F₅OPS₃
• Molecular Weight: 338.28
• UNSPSC Code: 12352005
• NACRES: NA.22

Properties

• form: powder
• Quality Level: 100
• mp: 94-97 °C

Description

Application

PSI² is a stable and sustainably prepared P(V) reagent developed by the Baran Lab for the synthesis of phosphorodithioate oligonucleotides. The phosphorodithioate linkages afforded by PSI² are effectively cleaved by RNAse-H while remaining stable to nucleases, and can be formed rapidly in high yield. The synthetic methodology accessed by PSI² and other PSI reagents (see ALD00602 and ALD00604) allows at will installation of a greater diversity of linkages to DNA and other nucleotides with comparable performance to existing state-of-the-art P(III) based reagents. The resulting compounds have applications in gene-based therapeutics such as antisense oligonucleotides (ASOs).

Learn more about PI and PSI reagents

Other Notes

Unlocking P(V): Reagents for chiral phosphorothioate synthesis

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable