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765260

Sigma-Aldrich

Gold nanoparticles

5 nm diameter, amine functionalized, PEG 3000 coated, OD 50, dispersion in H2O

Synonym(s):

Gold nanoparticles NH2 functionalized, Au NP NH2, Gold Colloid

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.23

material

PEG 3000

form

dispersion in H2O
nanoparticles

packaging

glass bottle of 1 mL

OD

50

diameter

5 nm

pH

6.0-8.0 (25 °C)

solubility

water: miscible

density

1.00 g/cm3

λmax

515 nm

functional group

amine

storage temp.

2-8°C

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Application

Amine functionalized, PEG 3000 coated, OD 50, and H2O dispersed gold nanoparticles (5 nm) can be used in the activation of silica nanosphere for the decomposition of formic acid. They may be used in the radiosensitization and imaging of cancer cells.
AuNPs can be potentially immobilized on antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19. They can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization, which can be used in the diagnosis of COVID-19.
Functionalized particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Features and Benefits

  • Negatively charged siRNA-PEG complex which is attached to positively charged GNPs is easily cleavable in reductive cytosolic environment thus enabling the release of siRNA into cytosol.
  • Decreases the cytotoxicity and increases efficiency of GNPs. PEG increases the stability of the nanoparticles and prevents agglomeration.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gold nanoparticles

Strong metal-molecular support interaction (SMMSI): amine-functionalized gold nanoparticles encapsulated in silica nanospheres highly active for catalytic decomposition of formic acid
Yadav M, et al.
Journal of Materials Chemistry, 22(25), 12582-12586 (2012)
Gold nanoparticles for radiosensitizing and imaging of cancer cells
Borran AA, et al.
Radiation Physics and Chemistry, 152(25), 137-144 (2018)
Optical Fiber Sensors for Rapid Screening of COVID-19
Nag P, et al.
Transactions of the Indian National Academy of Engineering, 152(25), 1-4 (2020)
Scott H Brewer et al.
Langmuir : the ACS journal of surfaces and colloids, 21(20), 9303-9307 (2005-09-21)
The interaction of bovine serum albumin (BSA) with gold colloids and surfaces was studied using zeta-potential and quartz crystal microbalance (QCM) measurements, respectively, to determine the surface charge and coverage. The combination of these two measurements suggests that BSA binding
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)

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