694509

3,3-Difluoropyrrolidine hydrochloride

97%

• Empirical Formula (Hill Notation): C₄H₇F₂N · HCl
• CAS Number: 163457-23-6
• Molecular Weight: 143.56
• MDL number: MFCD03788948
• UNSPSC Code: 12352100
• PubChem Substance ID: 329761667
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 97%
• form: solid
• mp: 133-136 °C
• functional group: fluoro
• SMILES string: Cl.FC1(F)CCNC1
• InChI: 1S/C4H7F2N.ClH/c5-4(6)1-2-7-3-4;/h7H,1-3H2;1H
• InChI key: YYVPZQADFREIFR-UHFFFAOYSA-N

Description

Application

3,3-Difluoropyrrolidine hydrochloride can be used as a building block in the synthesis of:

• Triazole substituted prolyl difluoropyrrolidines as potential inhibitors of dipeptidyl peptidase-4.
• Dual leucine zipper kinase (DLK) inhibitors.

It can be also used as a reactant in the preparation of cyclic and acyclic β-aminofluoroalkenes via allylic amination using the Pd catalyst.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves