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358894

Sigma-Aldrich

O-Tritylhydroxylamine

95%

Synonym(s):

O-(Triphenylmethyl)hydroxylamine, Trityloxyamine

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About This Item

Linear Formula:
(C6H5)3CONH2
CAS Number:
31938-11-1
Molecular Weight:
275.34
Beilstein:
1983917
EC Number:
250-868-1
MDL number:
MFCD00042818
UNSPSC Code:
12352100
PubChem Substance ID:
24862034
NACRES:
NA.22

Assay

95%

mp

79-81 °C (lit.)

SMILES string

NOC(c1ccccc1)(c2ccccc2)c3ccccc3

InChI

1S/C19H17NO/c20-21-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H,20H2

InChI key

NZFHJBSDSXDUAO-UHFFFAOYSA-N

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Application

O-Tritylhydroxylamine may be used in the preparation of 8-azido-O-trityloctahydroxamate and 9-azido-O-tritylnonahydroxamate. It may be used in the synthesis of Simian virus nuclear localization peptide (NLS)-histone deacetylase (HDAC) inhibitor conjugates.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Joshua C Canzoneri et al.
Bioorganic & medicinal chemistry letters, 19(23), 6588-6590 (2009-10-27)
We describe herein the synthesis and characterization of a new class of histone deacetylase (HDAC) inhibitors derived from conjugation of a suberoylanilide hydroxamic acid-like aliphatic-hydroxamate pharmacophore to a nuclear localization signal peptide. We found that these conjugates inhibited the histone
Vishal Patil et al.
Bioorganic & medicinal chemistry, 18(1), 415-425 (2009-11-17)
Histone deacetylase inhibitors (HDACi) are endowed with plethora of biological functions including anti-proliferative, anti-inflammatory, anti-parasitic, and cognition-enhancing activities. Parsing the structure-activity relationship (SAR) for each disease condition is vital for long-term therapeutic applications of HDACi. We report in the present
Francisco J Prado-Prado et al.
Bioorganic & medicinal chemistry, 18(6), 2225-2231 (2010-02-27)
There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one parasite species. Consequently, predicting the probability with which a drug is active against

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