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1′-Hydroxymidazolam

Name: 1&#8242;-Hydroxymidazolam
Brand: SIGMA

≥97% (HPLC), powder

Synonym(s):

8-Chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5a][1,4]benzodiazepine

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₃ClFN₃O

CAS Number:

59468-90-5

Molecular Weight:

341.77

UNSPSC Code:

12161501

PubChem Substance ID:

24724655

NACRES:

NA.77

MDL number:

MFCD00871458

Form:

powder

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Properties

Product Name

1′-Hydroxymidazolam,

form

powder

Quality Segment

200

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

white to off-white

storage temp.

2-8°C

SMILES string

OCc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4-n12

InChI

1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2

InChI key

QHSMEGADRFZVNE-UHFFFAOYSA-N

Description

General description

1′-Hydroxymidazolam is the metabolite of midazolam.

Application

CYP3A4 metabolite of midazolam.

1′-Hydroxymidazolam (1′-OHMDZ) can be used for assessing Cyp3a11 enzyme activity as well as for pharmacokinetic (PK) study of midazolam.

Biochem/physiol Actions

1′-Hydroxymidazolam is the major hydroxylated metabolite of Midazolam (MDZ), forms due to rapid and extensive metabolization of MDZ by the CYP 450 3A isoenzymes in the liver. The product contributes to the pharmacological impact of MDZ.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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This Item	M2419	Y0000599	Y0000562
Sigma-Aldrich UC430 1′-Hydroxymidazolam	Sigma-Aldrich M2419 Midazolam maleate salt	Y0000599 Midazolam for system suitability	Y0000562 Midazolam impurity C
description -	description -	description European Pharmacopoeia (EP) Reference Standard	description European Pharmacopoeia (EP) Reference Standard
form powder	form -	form -	form -
drug control regulated under CDSA - not available from Sigma-Aldrich Canada	drug control kontrollierte Droge in Deutschland, USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet	drug control regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet, kontrollierte Droge in Deutschland	drug control -
Quality Level 200	Quality Level 300	Quality Level -	Quality Level -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
color white to off-white	color -	color -	color -

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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