The stability of this product in solution has not been determined. However, pharmaceutical preparations in the form of solutions or ointments appear to be fairly stable when refrigerated. See the link below for a publication that may be helpful:
https://www.cjhp-online.ca/index.php/cjhp/article/view/659.
T4014
Tobramycin
Aminoglycoside antibiotic
Synonym(s):
3′-Deoxykanamycin B, Nebramycin Factor 6, O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine
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About This Item
Empirical Formula (Hill Notation):
C18H37N5O9
CAS Number:
Molecular Weight:
467.51
UNSPSC Code:
51281626
NACRES:
NA.85
PubChem Substance ID:
EC Number:
251-322-5
Beilstein/REAXYS Number:
1357507
MDL number:
Pricing and availability is not currently available.
biological source
Streptomyces tenebrarius
Quality Level
form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
concentration
≥900 μg/mg (anhydrous)
color
white to off-white
antibiotic activity spectrum
Gram-negative bacteria
mode of action
protein synthesis | interferes
storage temp.
2-8°C
SMILES string
NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
InChI
1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1
InChI key
NLVFBUXFDBBNBW-SNGYORCQSA-N
General description
Chemical structure: aminoglycoside
Application
Biochem/physiol Actions
Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16S rRNA (ribosomal RNA). It inhibits translocation and elicits miscoding.[6]
Tobramycin is used to treat Pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis, and other soft-tissue infections. It is a potential therapy for sinus infections.[7]
Tobramycin is used to treat Pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis, and other soft-tissue infections. It is a potential therapy for sinus infections.[7]
Tobramycin is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
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This Item | |||
|---|---|---|---|
| mode of action protein synthesis | interferes | mode of action - | mode of action - | mode of action - |
| antibiotic activity spectrum Gram-negative bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level - |
| form powder | form - | form solid | form - |
| biological source Streptomyces tenebrarius | biological source - | biological source - | biological source - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
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signalword
Warning
hcodes
Hazard Classifications
Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Ismini Nakouti et al.
Biotechnology progress, 33(1), 37-44 (2016-10-30)
Stress, caused by exposure to microwaves (2.45 GHz) at constant temperature (37 ± 0.5°C), alters the growth profile of Pseudomonas aeruginosa PAO1. In the absence of microwave treatment a simple, highly reproducible growth curve was observed over 24 h or more. Microwave treatment caused
Quentin Vicens et al.
Journal of molecular biology, 326(4), 1175-1188 (2003-02-19)
Aminoglycosides are antibacterial molecules that decrease translation accuracy by binding to the decoding aminoacyl-tRNA site (A site) on 16S ribosomal RNA. We have solved the crystal structure of an RNA fragment containing the A site bound to geneticin at 2.40A
R D Meyer et al.
Applied microbiology, 22(6), 1147-1151 (1971-12-01)
Tobramycin (factor 6 of the nebramycin complex) is a new aminoglycoside antibiotic isolated from Streptomyces tenebrarius which is active against S. aureus, Enterobacteriaceae, and Pseudomonas aeruginosa. Susceptibility to tobramycin of 96 strains of P. aeruginosa, including 45 recent isolates from
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T4014-100MG | 04061837345357 |
| T4014-500MG | 04061837345371 |
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What are the recommandations for the storage time and temperature of an aqueous solution of of Tobramycin please?
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