SML3597

ARUK3001185

≥98% (HPLC)

• Synonym(s): 1-[2,4-Dichloro-3-(trifluoromethyl)phenyl]-1H-1,2,3-triazole
• Empirical Formula (Hill Notation): C₉H₄Cl₂F₃N₃
• CAS Number: 2411969-39-4
• Molecular Weight: 282.05
• UNSPSC Code: 12352200
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: ClC1=C(C(Cl)=CC=C1N2C=CN=N2)C(F)(F)F
• InChI: 1S/C9H4Cl2F3N3/c10-5-1-2-6(17-4-3-15-16-17)8(11)7(5)9(12,13)14/h1-4H
• InChI key: XVFXHCLMGYJAQI-UHFFFAOYSA-N

Description

Biochem/physiol Actions

ARUK3001185 is a brain-penetrant, orally available, potent and selective carboxylesterase Notum inhibitor (IC50 = 6.7 nM) and Wnt signaling activator with no cross-reactivity toward panels of 39 serine hydrolases, 485 kinases (IC50 >10 μM), and 47 human off-target liabilities (IC50 >30 μM).

Brain-penetrant, orally available, potent and selective carboxylesterase Notum inhibitor and Wnt signaling activator.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable