SML3416

Hinokiflavone

≥97% (HPLC)

• Synonym(s): 4′,5,5′′,7,7′′-Pentahydroxy-4′′′,6-oxydi-flavone (8CI), 6-[4-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• Empirical Formula (Hill Notation): C₃₀H₁₈O₁₀
• CAS Number: 19202-36-9
• Molecular Weight: 538.46
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00017455
• Assay: ≥97% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: [o]1c2c([c](cc1c6ccc(cc6)O)=O)c(c(c(c2)O)Oc3ccc(cc3)c4[o]c5c([c](c4)=O)c(cc(c5)O)O)O
• InChI: 1S/C30H18O10/c31-16-5-1-14(2-6-16)24-12-21(35)28-26(40-24)13-22(36)30(29(28)37)38-18-7-3-15(4-8-18)23-11-20(34)27-19(33)9-17(32)10-25(27)39-23/h1-13,31-33,36-37H
• InChI key: WTDHMFBJQJSTMH-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Hinokiflavone is a plant biflavone that exhibit potent anticancer, hepatoprotective, antibacterial, antiviral, and anti-inflammatory activities. Hinokiflavone induces apoptosis and cell cycle arrest, and blocks migration and invasion of melanoma cells. It is a potent inhibitor of dengue 2 virus RNA-dependent RNA polymerase (DV-NS5 RdRp). Hinokiflavone is a modulator of pre-mRNA splicing in cells. It increases SUMOylation of a subset of spliceosome proteins by inhibiting SENP1 protease activity. It induces apoptosis in esophageal squamous cell carcinoma (ESCC) through regulation of PI3K/AKT/mTOR pathway.

Modulator of pre-mRNA splicing in cells; potent inhibitor of dengue 2 virus RNA-dependent RNA polymerase (DV-NS5 RdRp)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable