SML3370

BI605906

≥98% (HPLC)

• Synonym(s): 3-Amino-4-(1,1-difluoro-propyl)-6-(4-methanesulfonyl-piperidin-1-yl)-thieno[2,3-b]pyridine-2-carboxylic acid amide, 3-Amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]-thieno[2,3-b]pyridine-2-carboxamide, BI 605906, BI-605906
• Empirical Formula (Hill Notation): C₁₇H₂₂F₂N₄O₃S₂
• CAS Number: 960293-88-3
• Molecular Weight: 432.51
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD22665698
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: , White to very dark gray
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CCC(F)(C1=C2C(SC(C(N)=O)=C2N)=NC(N3CCC(CC3)S(C)(=O)=O)=C1)F
• InChI: 1S/C17H22F2N4O3S2/c1-3-17(18,19)10-8-11(23-6-4-9(5-7-23)28(2,25)26)22-16-12(10)13(20)14(27-16)15(21)24/h8-9H,3-7,20H2,1-2H3,(H2,21,24)
• InChI key: IYHHRZBKXXKDDY-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BI605906 is a selective, ATP-competitive IκB kinase β (IKK2, IKKβ, IKK-beta) inhibitor (IC50 = 380 nM, [ATP] = 0.1 mM) with no potency toward 100 other kinases, including IKKα, IKKε, TBK1, and IGF1R (IC50 ≥7.6 µM). BI605906 (10 µM) effectively blocks IKK-β-dependent phosphorylation of IKKε and TBK1 in IKKα-/- MEFs upon IL-1α (5 ng/mL) induction.

Sective, ATP-competitive IκB kinase β (IKK2, IKKβ, IKK-beta) inhibitor with no potency toward 100 other kinases, including IKKα, IKKε, TBK1, and IGF1R.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable