SML2297
Chlorflavonin
≥98% (HPLC), Antibiotic, powder
Synonym(s):
2-(3-Chloro-2-hydroxyphenyl)-5-hydroxy-3,7,8-trimethoxy-4H-1-benzopyran-4-one, F1484
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About This Item
Empirical Formula (Hill Notation):
C18H15ClO7
CAS Number:
Molecular Weight:
378.76
UNSPSC Code:
51111800
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
Product Name
Chlorflavonin, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC1=CC(OC)=C(C2=C1C(C(OC)=C(C3=C(O)C(Cl)=CC=C3)O2)=O)OC
InChI
1S/C18H15ClO7/c1-23-11-7-10(20)12-14(22)18(25-3)15(26-17(12)16(11)24-2)8-5-4-6-9(19)13(8)21/h4-7,20-21H,1-3H3
InChI key
JLSQXYITDXJTKL-UHFFFAOYSA-N
Related Categories
Biochem/physiol Actions
Antifungal against certain species of mold fungi and a superior antibiotic than streptomycin against M. tuberculosis by targeting AHAS catalytic subunit IlvB1.
Originally isolated from Aspergillus candidus Link, Chlorflavonin is a non-cytotoxic (up to 100 μM; MRC-5 and THP-1) antibiotic with antifungal activity against certain species of mold fungi (MIC = 0.08 μg/mL against A. amstelodami, A. fumigalus, A. ochraceous; Paecilomyces variotii MIC = 2.5 μg/mL, Botrytis cinerea MIC = 5 μg/mL). Chlorflavonin also exhibits antibiotic activity against M. tuberculosis (MIC90 = 1.56 μM) by targeting acetohydroxyacid synthase (AHAS) catalytic subunit ilvB1. Chlorflavonin is superior to streptomycin against M. tuberculosis inside infected macrophages, synergizes with isoniazid and delamanid, leading to a complete sterilization in liquid cultures.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Nidja Rehberg et al.
ACS infectious diseases, 4(2), 123-134 (2017-11-08)
The flavonoid natural compound chlorflavonin was isolated from the endophytic fungus Mucor irregularis, which was obtained from the Cameroonian medicinal plant Moringa stenopetala. Chlorflavonin exhibited strong growth inhibitory activity in vitro against Mycobacterium tuberculosis (MIC90 1.56 μM) while exhibiting no
Inge Kjærbølling et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(4), E753-E761 (2018-01-11)
The fungal genus of Aspergillus is highly interesting, containing everything from industrial cell factories, model organisms, and human pathogens. In particular, this group has a prolific production of bioactive secondary metabolites (SMs). In this work, four diverse Aspergillus species (A.
J E Munden et al.
Applied microbiology, 19(5), 718-720 (1970-05-01)
Production of chlorflavonin, a new antifungal antibiotic, by strains of Aspergillus candidus is described. Two wild strains of the fungus had distinctly different chlorflavonin-producing capabilities. One strain produced 25 mug of chlorflavonin per ml per 4 to 5 days in
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2297-25MG | 04061835307357 |
| SML2297-5MG | 04061835307364 |
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