SML0616

nTZDpa

≥98% (HPLC)

• Synonym(s): 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
• Empirical Formula (Hill Notation): C₂₂H₁₅Cl₂NO₂S
• CAS Number: 118414-59-8
• Molecular Weight: 428.33
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: S(c4ccccc4)c1c2c([n](c1C(=O)O)Cc3ccc(cc3)Cl)ccc(c2)Cl
• InChI: 1S/C22H15Cl2NO2S/c23-15-8-6-14(7-9-15)13-25-19-11-10-16(24)12-18(19)21(20(25)22(26)27)28-17-4-2-1-3-5-17/h1-12H,13H2,(H,26,27)
• InChI key: VUPOTURDKDMIGQ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

nTZDpa is a non-thiazolidinedione PPARγ partial agonist and selective PPARγ modulator (SPPARγM).

nTZDpa is a non-thiazolidinedione PPARγ partial agonist and selective PPARγ modulator (SPPARγM). nTZDpa binds to PPARγ with high affinity, but partially activates the receptor in cell-based assays. nTZDpa reduces insulin resistance and hyperglycemia in obese diabetic rodents equal to TZD full agonists, but without increasing cardiac weight and adiposity.

Features and Benefits

This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable