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Key Documents

SCP0105

Sigma-Aldrich

Caspase Substrate, chromogenic

≥95% (HPLC), lyophilized

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About This Item

Empirical Formula (Hill Notation):
C31H43N9O14
Molecular Weight:
765.73
UNSPSC Code:
12352202
NACRES:
NA.32

product name

Caspase Substrate, chromogenic,

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥75%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Ac-Val-Asp-Gln-Gln-Asp-pNA

Application

Ac-VDQQD-pNA (acetyl-Val-Asp-Gln-Gln-Asp-p-nitroanilide) is used as a chromogenic caspase substrate.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Gary K Smith et al.
Archives of biochemistry and biophysics, 399(2), 195-205 (2002-03-13)
Because of the intimate role of caspase-8 in apoptosis signaling pathways from FAS, TNFR1, and other death receptors, the enzyme is a potentially important therapeutic target. We have generated an Escherichia coli expression construct for caspase-8 in which a His-tag
Vasoactive intestinal peptide inhibits TNF-α-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands.
Calafat M, Larocca L, Roca V, Hauk V, et al.
Arthritis Research, 11, R53-R53 (2009)
Natasha Ann Pereira et al.
Biochemical and biophysical research communications, 377(3), 873-877 (2008-11-04)
Many designated substrates and inhibitors have been widely used to investigate the roles of caspases in apoptotic death during mammalian cell culture. However, the specificities of these substrates and inhibitors have not been systematically evaluated. As a result, conclusions on

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