S6256

Sulfamethazine

99.0-101.0% (on dried basis)

• Synonym(s): 4,6-Dimethylsulfadiazine, 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide, Sulfadimethyldiazine, Sulfadimidine
• Empirical Formula (Hill Notation): C₁₂H₁₄N₄O₂S
• CAS Number: 57-68-1
• Molecular Weight: 278.33
• UNSPSC Code: 51284910
• NACRES: NA.85
• PubChem Substance ID: 24899686
• EC Number: 200-346-4
• Beilstein/REAXYS Number: 261304
• MDL number: MFCD00006066

Properties

• Quality Segment: 200
• assay: 99.0-101.0% (on dried basis)
• form: powder or crystals
• storage condition: (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
• color: white to off-white
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1
• InChI: 1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)
• InChI key: ASWVTGNCAZCNNR-UHFFFAOYSA-N

Description

General description

Chemical structure: sulfonamide

Application

Sulfamethazine is an antibiotic used to treat bronchitis, prostatitis and urinary tract infections[1]. It is used in disposition and depletion kinetic studies[2][3]. It is used to develop detection techniques for quantification in fluids such as cows′ milk, honey and swine urine[4].

Biochem/physiol Actions

An antimicrobial sulfur drug. Induces CYP3A4 expression and acetylated by N-acetyltransferase. Exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11.

Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid[1]. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.

Packaging

25G,100G

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Safety Information

• Storage Class: 11 - Combustible Solids
• ppe: Eyeshields, Gloves, type N95 (US)
• pictograms: GHS07
• signalword: Warning
• hcodes: H315
• pcodes: P264 - P280 - P302 + P352 - P332 + P313 - P362 + P364
• Hazard Classifications: Skin Irrit. 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable