P6993
Protein Phosphatase 2A1 bovine
≥1500 units/mg protein
Synonym(s):
PPA2A1
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About This Item
Specific activity:
≥1500 units/mg protein
Assay:
≥90% (SDS-PAGE)
Biological source:
bovine
Pricing and availability is not currently available.
biological source
bovine
Quality Segment
assay
≥90% (SDS-PAGE)
form
solution
specific activity
≥1500 units/mg protein
mol wt
192 kDa
packaging
vial of 1 μg
shipped in
dry ice
storage temp.
−70°C
General description
Application
Protein phosphatase 2A1 has been used to treat human fibroblast cells prior to western blot analysis[4].
Biochem/physiol Actions
Protein Phosphatase 2A is a cytoplasmic protein, which colocalizes with microtubule proteins and is involved in the dephosphorylation of the tau protein and oncoprotein 18. Protein Phosphatase 2A1 (PP2A1) binds to polymerized microtubule proteins and may be targeted by tubulin in modulating phosphatase activity.[1] PP2A1 is implicated as a growth suppressor and is associated with dysregulation in cancer.[2] It also regulates cell cycle, RNA splicing differentiation, and signal transduction.[2] PP2A dysfunction is correlated to the tau protein deregulation in Alzheimer′s disease pathophysiology.[3] Protein Phosphatase 2A1 is a divalent cation-dependent protein serine/threonine phosphatase implicated as a growth suppressor and is associated with dysregulation in cancer.
Physical form
Solution in 50 mM Tris-HCl, pH 7.0, containing 14 mM 2-mercaptoethanol, 1 mM benzamidine, 0.1 mM PMSF, 1 mM EDTA, and 50% glycerol
Other Notes
One unit will release 1.0 nanomole of phosphate from 32P-labeled phosphorylase A per minute at pH 7.0 at 30 °C.
1 of 1
This Item | |||
|---|---|---|---|
| specific activity ≥1500 units/mg protein | specific activity ~2.0 U/vial | specific activity ~1000 units/mg protein | specific activity 5,000-15,000 units/mg protein |
| biological source bovine | biological source bovine kidney | biological source bovine brain | biological source rabbit |
| assay ≥90% (SDS-PAGE) | assay - | assay >90% (SDS-GE) | assay ≥80% (GE) |
| form solution | form buffered aqueous glycerol solution | form buffered aqueous glycerol solution | form lyophilized powder |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −20°C |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in - |
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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