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Phytosphingosine hydrochloride

Name: Phytosphingosine hydrochloride
Brand: SIGMA

Greener Alternative

Synonym(s):

4-Hydroxysphinganine, D-Ribo-1,3,4-trihydroxy-2-aminooctadecane, D-Ribo-2-aminooctadecane-1,3,4-triol, PHS

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₃₉NO₃ · HCl

CAS Number:

554-62-1

Molecular Weight:

353.97

NACRES:

NA.25

PubChem Substance ID:

24898363

UNSPSC Code:

12352211

MDL number:

MFCD06804643

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Properties

form

powder

Quality Segment

200

greener alternative product score

old score: 19
new score: 9
Find out more about DOZN™ Scoring

greener alternative product characteristics

Less Hazardous Chemical Syntheses
Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

greener alternative category

, Re-engineered

lipid type

sphingolipids

storage temp.

−20°C

SMILES string

Cl.CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO

InChI

1S/C18H39NO3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20;/h16-18,20-22H,2-15,19H2,1H3;1H/t16-,17+,18-;/m0./s1

InChI key

GDKAAHDFPOWGQE-RXQQAGQTSA-N

Description

Biochem/physiol Actions

Phytosphingosine is a long chain sphingoid base that occurs broadly in yeast, plants and animals including mammals. In yeast it is involved in mediating the heat stress response, perhaps through activation of the AGC-type protein kinases, Pkh1, Pkh2, Ypk1, Ypk2, and Sch9. It is proapoptotic in human cancer cell lines. PHS induces ΔΨ_m and release of cytochrome c from mitochondria either directly or through activation of p38 MAPK pathway. This leads to activation of caspase 9 followed by activation of caspase 3 and programmed cell death.

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This Item	860852P	860618P	SML1806
Sigma-Aldrich P2795 Phytosphingosine hydrochloride	Avanti 860852P CER9 (t18:0/26:0/18:1(d9))	Avanti 860618P CER6-2′R(d9)	Sigma-Aldrich SML1806 YU142670
description -	description Avanti Research^™ - A Croda Brand 860852P, powder	description Avanti Research^™ - A Croda Brand 860618P, powder	description ≥98% (HPLC)
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C
form powder	form powder	form powder	form powder
Quality Level 200	Quality Level -	Quality Level -	Quality Level 100
greener alternative product characteristics Less Hazardous Chemical Syntheses Safer Solvents and Auxiliaries Use of Renewable Feedstocks Learn more about the Principles of Green Chemistry.	greener alternative product characteristics -	greener alternative product characteristics -	greener alternative product characteristics -
lipid type sphingolipids	lipid type -	lipid type -	lipid type -
sustainability Greener Alternative Product	sustainability -	sustainability -	sustainability -

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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