P118

Phaclofen

solid

• Synonym(s): 3-Amino-2-(4-chlorophenyl)propanephosphonic acid
• Empirical Formula (Hill Notation): C₉H₁₃ClNO₃P
• CAS Number: 114012-12-3
• Molecular Weight: 249.63
• NACRES: NA.32
• PubChem Substance ID: 24278189
• UNSPSC Code: 12352200
• MDL number: MFCD00069328

Properties

• form: solid
• Quality Segment: 100
• impurities: ≥97% (NMR)
• color: white
• solubility: 0.1 M HCl: 13.3 mg/mL, methanol: 19.3 mg/mL, DMSO: insoluble
• SMILES string: NCC(CP(O)(O)=O)c1ccc(Cl)cc1
• InChI: 1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14)
• InChI key: VSGNGLJPOGUDON-UHFFFAOYSA-N
• Gene Information: human ... GABBR1(2550), GABBR2(9568)

Description

General description

Phaclofen is a phosphonic acid derivative of baclofen.

Application

Phaclofen has been used to block GABAB receptor.

Biochem/physiol Actions

Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (−) baclofen interact. Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K⁺ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves