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I1146
R3 IGF-1 human
recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
Human IGF-1, IGF-1 Protein, Recombinant IGF-1
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About This Item
UNSPSC Code:
51111800
NACRES:
NA.77
Pricing and availability is not currently available.
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biological source
human
Quality Level
recombinant
expressed in E. coli
Assay
≥85% (HPLC)
form
lyophilized powder
potency
≤10 ng/mL ED50
quality
endotoxin tested
mol wt
7,676 Da
packaging
pkg of 0.1 mg
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
2-8°C
Gene Information
human ... IGF1(3479)
Application
R3 IGF-I is a recombinant analog of insulin-like growth factor containing the complete human IGF-I amino acid sequence with substitution of Arg for Glu3. It was developed as an inexpensive, high quality potent analog of IGF for use as a growth factor supplement for serum-free or low serum cell culture.
Recombinantly produced in E. coli using a patented expression system, the peptide is harvested from cells in inclusion bodies, which are dissolved and desalted. The active molecule is properly folded under oxidizing conditions and then purified by several liquid chromatography steps.
Recombinantly produced in E. coli using a patented expression system, the peptide is harvested from cells in inclusion bodies, which are dissolved and desalted. The active molecule is properly folded under oxidizing conditions and then purified by several liquid chromatography steps.
Biochem/physiol Actions
Proliferation of chinese hamster ovary CHO cells.
Other Notes
Recombinant analog of insulin-like growth factor-I with the substitution of Arg for Glu at position 3.
Preparation Note
Prepared from 0.1 M acetic acid
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Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Articles
Insulin-like Growth Factors (IGF)
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What is the Department of Transportation shipping information for this product?
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How do the sequences of Products I1146 and I1271 compare to that of native Insulin-like Growth Factor 1 (IGF-1)?
1 answer-
The entire IGF-1 gene codes for 194 amino acids, but the mature form of the protein is 70 amino acids, consisting of amino acids 49-118.Product I1146 is R3 IGF-1, which is also 70 amino acids in length. The Glutamic acid (E) at position 3 has simply been replaced by an Arginine (R). So the sequence of Product I1146 is:GP RTLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSAProduct I1271 is the same as I1146, but with an additional thirteen amino acids "in front of" the normal N-terminus of the R3 IGF-1:MFPAM PLSSLFVNGP RTLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSANote that the first 13 amino acids in the recombinant I1271 (MFPAMPLSSLFVN)are quite different from what would have been the preceding 13 amino acids in the immature IGF-1.
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