Skip to Content
Merck

Key Documents

View All Documentation

Skip To

G8048

GLP-1R agonist

≥98% (HPLC), powder, glucose homeostasis regulator

Synonym(s):

2-Quinoxalinamine, 6,7-dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-, 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline (DMB), Compound 2

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice

About This Item

Empirical Formula (Hill Notation):
C13H15Cl2N3O2S
CAS Number:
281209-71-0
Molecular Weight:
348.25
MDL number:
MFCD11521508
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Pricing and availability is not currently available.
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

GLP-1R agonist, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

light brown-yellow

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(C)c1nc2c(nc1NC(C)(C)C)cc(c(c2)Cl)Cl

InChI

1S/C13H15Cl2N3O2S/c1-13(2,3)18-11-12(21(4,19)20)17-10-6-8(15)7(14)5-9(10)16-11/h5-6H,1-4H3,(H,16,18)

InChI key

GNZCSGYHILBXLL-UHFFFAOYSA-N

General description

Glucagon-like peptide-1 receptor (GLP-1R) agonist is a potential oral drug for modulating glucagon-like peptide (GLP)-1 in diabetic patients. GLP-1R agonists play a key role in lowering glycated hemoglobin levels. It improves glycemic control and maintenance of body weight.

Biochem/physiol Actions

GLP-1R is a small molecule GLP-1 receptor agonist.
GLP-1R is a small molecule GLP-1 receptor agonist. GLP-1 receptor signaling is a predominant mechanism for regulating glucose homeostasis. This compound represents a unique non-peptide tool for studying the role of GLP-1 in both in vivo and in vitro diabetes and obesity models.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

1–3 of 3 Questions  

  1. Is it possible to resuspend the aginist in DMSO and then dilute it in PBS without causing precipitation or affecting its solubility, with the goal of injecting it into a murine ?model

    1 answer

    1. This product has not been studied in-house for in vivo applications. Please refer to published literature for relevant citations regarding its use in murine models.

      Helpful?

  2. What is the mechanism of action for this compound? Additionally, is the structural information available for this compound?

    What is the mechanism of action for this compound? Additionally, is the structural information available for this compound?

    1 answer

    1. The compound known as compound 2 was discovered through functional screening, demonstrating that it enhances the binding of GLP-1 to the receptor rather than competing with it. It functions as an ago-allosteric modulator, acting as both an agonist and an allosteric modulator. This compound is specific to the GLP-1 receptor and induces insulin release from wild-type mouse islets, as detailed in a specific article. For information on the structure of compound 2, please refer to Figure 2 in the publication "Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3): 937–942." The PMID for the article is 17213325, and it can be accessed at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783418/.

      Helpful?

  3. What is the molecular weight of GLP1 agonist 8048 in grams ?

    1 answer

    1. The molecular weight of this product is 348.25. This value can be interpreted in units of daltons or grams per mole.

      Helpful?

Reviews

No rating value

Active Filters