C8791

Monoclonal Anti-Cytokeratin Peptide 14 antibody produced in mouse

clone CKB1, ascites fluid

• Synonym(s): Anti-CK14, Anti-EBS1, Anti-EBS1A, Anti-EBS1B, Anti-EBS1C, Anti-EBS1D, Anti-EBS3, Anti-EBS4, Anti-K14, Anti-NFJ
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD00162249
• Conjugate: unconjugated
• Clone: CKB1, monoclonal
• Application: IF, IHC (f), IHC (p)
• Citations: 13

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: ascites fluid
• antibody product type: primary antibodies
• clone: CKB1, monoclonal
• contains: 15 mM sodium azide
• species reactivity: human
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunohistochemistry (frozen sections): suitable, indirect immunofluorescence: 1:200 using methacarn-fixed, paraffin-embedded human tissue sections
• isotype: IgM
• UniProt accession no.: P02533
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... KRT14(3861)

Description

General description

Monoclonal Anti-Cytokeratin Peptide 14 (mouse IgM isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Keratin 14 (KRT14) is expressed in keratinocytes and localized to the basal epidermal layer. The gene is mapped to human chromosome 17q21 and encodes an intermediate filament.

Immunogen

human callus keratins.

Application

Monoclonal Anti-Cytokeratin Peptide 14 antibody produced in mouse has been used in indirect immunofluorescence or immunoperoxidase techniques.

Biochem/physiol Actions

Keratin 14 (KRT14) is associated with maintaining cellular stability. Mutation in the KRT14 gene leads to epidermolysis bullosa simplex, a genetic disorder. It is known to promote angiogenesis, cell migration and proliferation in cancer cells.

The antibody reacts with myoepithelial cells in various organs (parotid, submandibular, mammary, prostate, and sweat glands) as well as with the basal layer of certain squamous epithelium (exocervical, laryngeal epithelium).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable