C2436
Cytochrome c from Saccharomyces cerevisiae
≥85% based on Mol. Wt. 12,588 basis
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About This Item
Form:
powder
Assay:
≥85% based on Mol. Wt. 12,588 basis
Biological source:
Saccharomyces cerevisiae
Mol wt:
12,588 Da
Pricing and availability is not currently available.
biological source
Saccharomyces cerevisiae
Quality Segment
assay
≥85% based on Mol. Wt. 12,588 basis
form
powder
mol wt
12,588 Da
technique(s)
cell based assay: suitable
solubility
water: 10 mg/mL, clear, red to red-brown (dark red)
UniProt accession no.
application(s)
cell analysis
storage temp.
−20°C
Gene Information
Saccharomyces cerevisiae ... CYC1(853507)
General description
Cytochrome c (Cytc) comprises 104 amino acids and is a nuclear-encoded mitochondrial protein. This peripheral membrane protein is in spherical shape and has a molecular weight of 12,000 Da.
Application
Cytochrome c from Saccharomyces cerevisiae has been used in oocyte injection to induce caspase-3 activation and p38 MAPK (mitogen-activated protein kinase). It has also been used to analyze the aerobic reactions of nitric oxide.
Biochem/physiol Actions
The ready fluctuation of cytochrome c within the cell between ferrous and ferric states, makes it an efficient biological electron-transporter. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal catalyst of respiration, it forms the essential electron-bridge between the respirable substrates and oxygen.
The ready fluctuation of cytochrome c within the cell between ferrous and ferric states, makes it an efficient biological electron-transporter. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal catalyst of respiration, it forms the essential electron-bridge between the respirable substrates and oxygen. Tracking cellular localization of cytochrome c in S. cerervisiae demonstrates that mitochondria are strongly involved in programmed cell death, a process very similar to apoptosis in higher organisms.
Cytochrome c (Cytc) participates in mitochondrial electron transport and intrinsic type II apoptosis. It plays a key role in aerobic energy production. This multi-functional enzyme serves as a single electron carrier. Cytc helps in the formation of the apoptosome.
Preparation Note
Prepared without using TCA.
Analysis Note
Care has been taken to maintain the native form of the protein. It has not been artificially oxidized or reduced during purification. Contains variable amounts of reduced cytochrome c.
Other Notes
View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.
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This Item | |||
|---|---|---|---|
| description ≥85% based on Mol. Wt. 12,588 basis | description Type I | description Type II | description - |
| assay ≥85% based on Mol. Wt. 12,588 basis | assay - | assay - | assay - |
| biological source Saccharomyces cerevisiae | biological source Saccharomyces cerevisiae | biological source Saccharomyces cerevisiae | biological source Saccharomyces cerevisiae |
| technique(s) cell based assay: suitable | technique(s) - | technique(s) - | technique(s) - |
| form powder | form powder or solid | form powder or solid | form powder |
| mol wt 12,588 Da | mol wt - | mol wt - | mol wt ~150,000 |
| UniProt accession no. | UniProt accession no. - | UniProt accession no. - | UniProt accession no. - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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