C0434

Chorionic gonadotropin human

lyophilized powder, from human pregnancy urine

• Synonym(s): Choriogonin, HCG
• CAS Number: 9002-61-3
• UNSPSC Code: 12352209
• EC Number: 232-660-2
• NACRES: NA.32
• MDL number: MFCD00130797
• Biological source: human pregnancy urine
• Form: lyophilized powder

Properties

• biological source: human pregnancy urine
• Quality Segment: 200
• sterility: sterile-filtered
• form: lyophilized powder
• potency: ~13,000 I.U. per mg
• mol wt: 37.9 kDa
• impurities: HBsAg, HCV and HIV-1/HIV-2, tested negative
• solubility: water: 2 mg/mL, clear, colorless
• UniProt accession no.: P01215
• shipped in: ambient
• storage temp.: −20°C
• Gene Information: human ... CGA(1081)

Description

General description

Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG.

Biochem/physiol Actions

Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals. When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.

Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.

Other Notes

Similar to C2047, but from a different supplier.

Safety Information

• pictograms: GHS08
• signalword: Warning
• hcodes: H361
• pcodes: P281
• Hazard Classifications: Repr. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable