This product is not tested for inducing an animal model of androgenic alopecia. Determination of suitability must be conducted experimentally.
A8380
5α-Androstan-17β-ol-3-one
synthetic, ≥97.5%, Androgen hormone, powder
Synonym(s):
17β-Hydroxy-5α-androstan-3-one, 4,5α-Dihydrotestosterone, Androstanolone, Stanolone
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About This Item
Empirical Formula (Hill Notation):
C19H30O2
CAS Number:
Molecular Weight:
290.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
208-307-3
MDL number:
Beilstein/REAXYS Number:
2056371
Assay:
≥97.5%
Form:
powder
Pricing and availability is not currently available.
Product Name
5α-Androstan-17β-ol-3-one, ≥97.5%
biological source
synthetic
Quality Segment
sterility
non-sterile
assay
≥97.5%
form
powder
drug control
USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
solubility
ethanol: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow
SMILES string
[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CCC(=O)C2
InChI
1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1
InChI key
NVKAWKQGWWIWPM-ABEVXSGRSA-N
Gene Information
human ... AR(367), ESR1(2099), PGR(5241), SERPINA6(866), SHBG(6462)
mouse ... Esr1(13982)
rat ... Ar(24208), Esr1(24890), Nr3c1(24413), Nr3c2(25672), Pgr(25154)
Application
5α-Androstan-17β-ol-3-one, also referred to as androstanolone or dihydrotestosterone, is an anabolic steroid. Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone, including the development of the male phenotype during embryogenesis and at puberty.
Biochem/physiol Actions
Androstanolone is an anabolic steroid. Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. Androgens direct the development of the male phenotype during embryogenesis and at puberty.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥97.5% | assay ≥99.0% (TLC) | assay ≥98% (TLC) | assay ≥97% (HPLC) |
| drug control USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada | drug control USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada | drug control USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada | drug control - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| solubility ethanol: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow | solubility - | solubility methanol: 19.60-20.40 mg/mL, clear, colorless | solubility methanol: 50 mg/mL, clear, colorless |
| Gene Information human ... AR(367), ESR1(2099), PGR(5241), SERPINA6(866), SHBG(6462) | Gene Information - | Gene Information rat ... Ar(24208) | Gene Information - |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 1A
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Is this product suitable for inducing an animal model of androgenic alopecia?
1 answer-
Helpful?
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Is it suitable to treat this in cell culture? I've already seen such recommendations.. However, the fact that it is not sterilized is a bit concerning. would it still be possible?
1 answer-
This product has not been tested for suitability in cell culture. While the powder is not sterile, prepared stock solutions may be filter sterilized. The material is soluble at 50 mg/mL in ethanol and may be further diluted using buffer or medium. The peer-reviewed papers listed on this page reference publications the have listed this product used in a number of applications successfully. There are several in vitro and in vivo applications cited. Please see the link below to review one example publication:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099410Helpful?
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