911429

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG average M_n 5,000, PLGA average M_n 5,000, lactide:glycolide 80:20

• Synonym(s): PEG-PLGA, PEG5K-PLGA5K, Polyethylene glycol, mPEG-b-PLGA
• Linear Formula: H[(C₃H₄O₂)_x(C₂H₂O₂)_y]_mO[C₂H₄O]_nCH₃
• UNSPSC Code: 12352112
• NACRES: NA.23

Properties

• form: powder
• feed ratio: lactide:glycolide 80:20
• mol wt: PEG average M_n 5,000 (by NMR); PLGA average M_n 5,000 (by NMR)
• impurities: ≤500 ppm (GC)
• color: white
• storage temp.: −20°C

Description

Application

This polymer is a amphiphilic diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLGA block. This biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable