910058

2-(2-(Oct-7-yn-1-yloxy)ethoxy)acetic acid

≥95%

• Synonym(s): 2-2-6 PROTAC^® linker, Alkyne-PEG₂-acid, Bifunctional linker
• Empirical Formula (Hill Notation): C₁₂H₂₀O₄
• Molecular Weight: 228.28
• UNSPSC Code: 12352106

Properties

• Assay: ≥95%
• form: (Viscous Liquid or Semi-solid or Paste or Solid)
• reaction suitability: reaction type: click chemistry; reagent type: linker
• functional group: alkyne; carboxylic acid
• storage temp.: 2-8°C
• SMILES string: OC(COCCOCCCCCCC#C)=O

Description

Application

This heterobifunctional, PEGylated crosslinker 2-(2-(oct-7-yn-1-yloxy)ethoxy)acetic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG₂-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-6.

Other Notes

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable